Contact Person

Dr. Iris Weiche

Managing Editor

Phone: +49 (0)711 - 2 29 87 36
Fax: +49 (0)711 - 2 29 87 65
send an Email

The free access does not apply to institutional or commercial use. 
Information: Opens window for sending


Marine Omega3 wound matrix for the treatment of complicated wounds

Journal: Phlebologie
ISSN: 0939-978X

Wundmanagement des Ulcus cruris venosum

Issue: 2016 (Vol. 45): Issue 2 2016 (69–128)
Pages: 93-98

Marine Omega3 wound matrix for the treatment of complicated wounds

Experiences associated with amputations in the lower limb in diabetic patients

T. T. Trinh (1), F. Dünschede (1), C.-F. Vahl (1), B. Dorweiler (1)

(1) Division of Vascular Surgery, Department of Cardiothoracic & Vascular Surgery, University Medical Center Mainz, Germany


wound healing, amputation, Diabetic ulcer, wound matrix


Introduction: Complicated wounds in the lower extremity can arise as a consequence of insufficient soft-tissue coverage after amputations in diabetic patients. The Kerecis® Omega3 wound matrix is a decellularized skin matrix derived from codfish and represents an alternative treatment option to achieve wound healing. Methods: 5 patients with diabetes mellitus and complicated wounds in the lower limb with exposed bony segments were treated with the Omega3 wound matrix between November 2014 and November 2015. Following initial debridement in the operating room, the wound matrix was applied and covered with a silicone mesh. In the further course, wound treatment was conducted on outpatient setting. Results: In total, 7 wounds were treated with localization at the level of the thigh (n=2) and the forefoot (n=5). For the wounds at the thigh, it took 26 weeks to achieve wound closure, whereas the wounds at the level of the forefoot showed healing times between 13 and 41 weeks. In all patients, a reduction of analgetics intake was noted when the treatment with the Omega3 wound matrix was initiated. Conclusion: The Kerecis® Omega3 wound matrix represents a viable treatment option in complicated wounds in the lower limb of diabetic patients to circumvent an otherwise necessary proximalization of amputation level. Further studies comparing the Omega3 wound matrix with appropriate control groups of standard therapies for soft-tissue conditioning/coverage like negative pressure therapy, biosurgery and other acellular dermal matrices are warranted.

You may also be interested in...

Ch. Uhlemann (1) , U. Wollina (2)

Phlebologie 2003 32 4: 81-86

Masayoshi Souri 1, Shiori Koseki-Kuno 1, Naoki Takeda 2, Mitsunori Yamakawa 3, Yasuchika Takeishi 4, Jay L. Degen 5, Akitada Ichinose1

Thromb Haemost 2008 99 2: 401-408

A. Franek1 , J. Taradaj, L. Cierpka 2 , E. Blaszczak

Phlebologie 2005 34 5: 255-261